Booth latched on to Pawel Abbott's lay-off after the former Poland Under-21 international dispossessed Walsall captain Chris Westwood on the edge of the box on 15 minutes.
Veteran Booth curled a low shot into the bottom right corner of the net to register his fourth league goal of the season and reach the century mark in his two separate spells at Huddersfield.
Booth returned the favour late on by setting up Abbott from Nat Clarke's long throw.
It was Abbott's second of the match after he had earlier turned in Danny Schofield's byline cross on 34 minutes.
Walsall's Paul Smith had cancelled out Booth's opener by heading in Mark Kinsella's free-kick after 31 minutes.
But once Abbott put the home side back in front Wallsall never looked like getting back into it.
The Saddlers were struggling with a major injury crisis involving 10 players before the game and things got worse as the match progressed.
Their six-goal top scorer Matty Fryatt had to be taken off just before half-time suffering from a virus and Joe Broad limped off on 57 minutes with an ankle injury to add to player-manager Paul Merson's woes.
Huddersfield's win could have been more emphatic but Jon Worthington hit the left hand post with a long-range effort in the opening minutes.
And Booth was denied when his header from a Tony Carss corner bounced off the inside of the post before being kicked off the line by Jorge Leitao after 70 minutes.
Walsall, who have now lost four times in their last seven games, could have got back into it in the closing stages but substitute David McDermott planted a header straight at Town keeper Paul Rachubka following David Mirfin's slip.